Mixed gliomas

General characteristics

Oligoastrocytoma (WHO grade II–IV) is composed of two distinct neoplastic cell types that morphologically resemble tumor cells in oligodendroglioma and diffuse astrocytoma

Epidemiology

The median age of patients is reported to range from 35 to 45 years.

Imaging and Location

This tumor has a predilection for the cerebral hemispheres; the frontal lobes are most commonly affected, followed by the temporal lobes.

Oligoastrocytomas appear similar to oligodendrogliomas on both CT and MRI with common calcifications. Cystic changes are also common; hemorrhage and edema are rare. The signal intensities are hypointense on T1 and hyperintense on long TR/TE sequence types.

Contrast enhancement

Contrast enhancement is seen in all grades with a stronger enhancement in the anaplastic and malignant forms.

Prognosis

One study reported a median survival time of 6.3 years.

Original

  1. M.F. Reiser, W. Semmler, H. Hricak (Eds.) "Magnetic Resonance Tomography", Springer 2008


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