Anaplastic gangliogliomas

General characteristics

Anaplastic gangliogliomas (WHO grade III), i.e., gangliogliomas that show anaplastic features in their glial component, are sometimes seen; rare cases exhibit WHO grade IV (glioblastoma) changes in the glial component.


These types of tumors account for 0.4% of all CNS tumors, 1.3% of all brain tumors, and can occur at any age. These types of tumors may occur throughout the CNS; most are supratentorial and involve the temporal lobe.

Imaging and Location

They present unspecific imaging findings with inhomogeneous hyperintensities on T2 and contrast enhancement in some cases (Fedi et al. 2004). Normally both cystic and solid components can be detected. The main differential diagnoses are pilocytic astrocytomas. The calcifications that are present in some of the cases might be helpful in this respect.


  1. M.F. Reiser, W. Semmler, H. Hricak (Eds.) "Magnetic Resonance Tomography", Springer 2008