Aging of the corpus callosum

Morphology

This relatively common malformation may be partial or complete, and isolated or combined with a variety of other malformations (Barkovitch and Norman 1988). It is found increasingly now that non-invasive imaging is used widely, and may be associated with very little neurological deficit. It is a feature of at least 12 syndromes (Aicardi 1998). Of particular interest is the Aicardi syndrome, which is associated with periventricular heterotopias, choroido-retinal lacunae, and vertebral anomalies (Fig. 4.10). This condition, which is confined to girls, presents with severe mental retardation and early onset infantile spasms. In Shapiro's syndrome there are features of hypothalamic dysfunction, particularly hypothermia (Shapiro et al. 1969). Agenesis of the corpus callosum may also occur in a number of metabolic diseases of the nervous system (Section 4.10).

Partial agenesis of the corpus callosum

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Fig. 10

Complete agenesis of corpus callosum

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Fig.11

Aicardi syndrome

Aicardi syndrome, showing widely spaced lateral ventricles with a high third ventricle, typical of agenesis of the corpus callosum, and a large mass of heterotopic grey matter in the left hemisphere (MRI; courtesy of Dr Kling Chong).




Author: Radiologist, Ph.D. Vlasov Evgeniy Alexandrovich

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